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Doctors may also prescribe amitriptyline for pain caused by a variety of conditions such as fibromyalgia , irritable bowel syndrome, migraine headaches and interstitial cystitis Amitriptyline is primarily used to treat major depressive disorder as well as other types of depression in adults and adolescents. Doctors may also prescribe amitriptyline for pain caused by a variety of conditions such as fibromyalgia , irritable bowel syndrome, migraine headaches and interstitial cystitis Endogenous depression is more likely to be alleviated than are other depressive states. However, it is also used to treat a variety of other conditions including anxiety disorders (including PTSD), ADHD, enuresis (bed wetting), bulimia, irritable bowel syndrome, chronic pain, chronic fatigue syndrome, migraine headaches, and smoking.. 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